Installation

HPOExplorer is now available via ghcr.io as a containerised environment with Rstudio and all necessary dependencies pre-installed.

Method 1: via Docker

First, install Docker if you have not already.

Create an image of the Docker container in command line:

docker pull ghcr.io/neurogenomics/HPOExplorer

Once the image has been created, you can launch it with:

docker run \
  -d \
  -e ROOT=true \
  -e PASSWORD="<your_password>" \
  -v ~/Desktop:/Desktop \
  -v /Volumes:/Volumes \
  -p 8900:8787 \
  ghcr.io/neurogenomics/HPOExplorer

NOTES

  • Make sure to replace <your_password> above with whatever you want your password to be.
  • Change the paths supplied to the -v flags for your particular use case.
  • The -d ensures the container will run in “detached” mode, which means it will persist even after you’ve closed your command line session.
  • The username will be “rstudio” by default.
  • Optionally, you can also install the Docker Desktop to easily manage your containers.

Method 2: via Singularity

If you are using a system that does not allow Docker (as is the case for many institutional computing clusters), you can instead install Docker images via Singularity.

singularity pull docker://ghcr.io/neurogenomics/HPOExplorer

For troubleshooting, see the Singularity documentation.

Usage

Finally, launch the containerised Rstudio by entering the following URL in any web browser: http://localhost:8900/

Login using the credentials set during the Installation steps.

Session Info

utils::sessionInfo()
## R Under development (unstable) (2025-11-30 r89082)
## Platform: x86_64-pc-linux-gnu
## Running under: Ubuntu 24.04.3 LTS
## 
## Matrix products: default
## BLAS:   /usr/lib/x86_64-linux-gnu/openblas-pthread/libblas.so.3 
## LAPACK: /usr/lib/x86_64-linux-gnu/openblas-pthread/libopenblasp-r0.3.26.so;  LAPACK version 3.12.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
##  [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
##  [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C            
## [11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## time zone: UTC
## tzcode source: system (glibc)
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
## [1] HPOExplorer_1.0.6
## 
## loaded via a namespace (and not attached):
##   [1] RColorBrewer_1.1-3        jsonlite_2.0.0           
##   [3] shape_1.4.6.1             magrittr_2.0.4           
##   [5] farver_2.1.2              rmarkdown_2.30           
##   [7] GlobalOptions_0.1.3       fs_1.6.6                 
##   [9] ragg_1.5.0                vctrs_0.6.5              
##  [11] ggtree_4.1.1              rstatix_0.7.3            
##  [13] htmltools_0.5.8.1         broom_1.0.10             
##  [15] Formula_1.2-5             gridGraphics_0.5-1       
##  [17] sass_0.4.10               bslib_0.9.0              
##  [19] htmlwidgets_1.6.4         desc_1.4.3               
##  [21] httr2_1.2.1               plotly_4.11.0            
##  [23] cachem_1.1.0              igraph_2.2.1             
##  [25] mime_0.13                 lifecycle_1.0.4          
##  [27] iterators_1.0.14          pkgconfig_2.0.3          
##  [29] Matrix_1.7-4              R6_2.6.1                 
##  [31] fastmap_1.2.0             shiny_1.11.1             
##  [33] clue_0.3-66               digest_0.6.39            
##  [35] aplot_0.2.9               colorspace_2.1-2         
##  [37] patchwork_1.3.2           S4Vectors_0.49.0         
##  [39] grr_0.9.5                 textshaping_1.0.4        
##  [41] ggpubr_0.6.2              httr_1.4.7               
##  [43] KGExplorer_0.99.10        abind_1.4-8              
##  [45] compiler_4.6.0            fontquiver_0.2.1         
##  [47] doParallel_1.0.17         S7_0.2.1                 
##  [49] backports_1.5.0           BiocParallel_1.45.0      
##  [51] orthogene_1.17.0          carData_3.0-5            
##  [53] homologene_1.4.68.19.3.27 maps_3.4.3               
##  [55] ggsignif_0.6.4            rappdirs_0.3.3           
##  [57] rjson_0.2.23              scatterplot3d_0.3-44     
##  [59] tools_4.6.0               otel_0.2.0               
##  [61] ape_5.8-1                 httpuv_1.6.16            
##  [63] glue_1.8.0                rols_2.99.5              
##  [65] nlme_3.1-168              promises_1.5.0           
##  [67] grid_4.6.0                cluster_2.1.8.1          
##  [69] generics_0.1.4            gtable_0.3.6             
##  [71] tidyr_1.3.1               data.table_1.17.8        
##  [73] tidygraph_1.3.1           xml2_1.5.1               
##  [75] car_3.1-3                 BiocGenerics_0.57.0      
##  [77] foreach_1.5.2             pillar_1.11.1            
##  [79] stringr_1.6.0             yulab.utils_0.2.2        
##  [81] babelgene_22.9            pals_1.10                
##  [83] later_1.4.4               circlize_0.4.16          
##  [85] dplyr_1.1.4               treeio_1.35.0            
##  [87] lattice_0.22-7            tidyselect_1.2.1         
##  [89] fontLiberation_0.1.0      ComplexHeatmap_2.27.0    
##  [91] knitr_1.50                fontBitstreamVera_0.1.1  
##  [93] IRanges_2.45.0            stats4_4.6.0             
##  [95] xfun_0.54                 Biobase_2.71.0           
##  [97] matrixStats_1.5.0         stringi_1.8.7            
##  [99] lazyeval_0.2.2            ggfun_0.2.0              
## [101] yaml_2.3.11               evaluate_1.0.5           
## [103] codetools_0.2-20          gdtools_0.4.4            
## [105] tibble_3.3.0              ggplotify_0.1.3          
## [107] Polychrome_1.5.4          cli_3.6.5                
## [109] xtable_1.8-4              systemfonts_1.3.1        
## [111] jquerylib_0.1.4           dichromat_2.0-0.1        
## [113] Rcpp_1.1.0                mapproj_1.2.12           
## [115] gprofiler2_0.2.4          png_0.1-8                
## [117] parallel_4.6.0            simona_1.9.0             
## [119] pkgdown_2.2.0             ggplot2_4.0.1            
## [121] viridisLite_0.4.2         tidytree_0.4.6           
## [123] ggiraph_0.9.2             scales_1.4.0             
## [125] purrr_1.2.0               crayon_1.5.3             
## [127] GetoptLong_1.1.0          rlang_1.1.6              
## [129] fastmatch_1.1-6           rvest_1.0.5