Authors: Robert Gordon-Smith, Brian Schilder, Nathan Skene
README updated: Nov-14-2023
MultiEWCE: Ontology-scale Cell Type Enrichment Analyses
The MultiEWCE R package allows you to run Expression Weighted Celltype Enrichment (EWCE) on multiple gene lists in parallel. It was primarily designed for use with the Human Phenotype Ontology, but can be easily adapted to any other gene lists. Finally, it includes pipelines for the systematic identification of cell type-specific gene therapy targets of diseases.
If you use MultiEWCE, please cite:
Kitty B. Murphy, Robert Gordon-Smith, Jai Chapman, Momoko Otani, Brian M. Schilder, Nathan G. Skene (2023) Identification of cell type-specific gene targets underlying thousands of rare diseases and subtraits. medRxiv, https://doi.org/10.1101/2023.02.13.23285820
Installation
if(!require("remotes")) install.packages("remotes")
remotes::install_github("neurogenomics/MultiEWCE")
library(MultiEWCE)