All functions

check_ldsc_format()

Ensures that parameters are compatible with LDSC format

compute_nsize()

Check for N column if not present and user wants, impute N based on user's sample size. NOTE this will be the same value for each SNP which is not necessarily correct and may cause issues down the line. N can also be inputted with "ldsc", "sum", "giant" or "metal" by passing one or multiple of these.

download_vcf()

Download VCF file and its index file from Open GWAS

find_sumstats()

Search Open GWAS for datasets matching criteria

format_sumstats()

Check that summary statistics from GWAS are in a homogeneous format

formatted_example()

Formatted example

get_genome_builds()

Infer genome builds

hg19ToHg38

UCSC Chain file hg19 to hg38

hg38ToHg19

UCSC Chain file hg38 to hg19

ieu-a-298

Local ieu-a-298 file from IEU Open GWAS

import_sumstats()

Import full genome-wide GWAS summary statistics from Open GWAS

index_tabular()

Tabix-index file: table

liftover()

Genome build liftover

list_sumstats()

List munged summary statistics

load_ref_genome_data()

Load the reference genome data for SNPs of interest

load_snp_loc_data()

Loads the SNP locations and alleles for Homo sapiens extracted from NCBI dbSNP Build 144. Reference genome version is dependent on user input.

parse_logs()

Parse data from log files

raw_ALSvcf

GWAS Amyotrophic lateral sclerosis ieu open GWAS project - Subset

raw_eduAttainOkbay

GWAS Educational Attainment Okbay 2016 - Subset

read_header()

Read in file header

read_sumstats()

Determine summary statistics file type and read them into memory

read_vcf()

Read in VCF file

register_cores()

Register cores

standardise_header()

Standardise the column headers in the Summary Statistics files

sumstatsColHeaders

Summary Statistics Column Headers

vcf2df()

VCF to DF

write_sumstats()

Write sum stats file to disk