Identify the overlap between your prioritised list of gene therapy targets and currently existing gene therapy targets that are currently on the market or are in clinical trials. Uses data from the Therapuetic Target Database.
ttd_check(
top_targets,
save_dir = tools::R_user_dir(package = "MultiEWCE", which = "cache"),
drug_types = NULL,
highest_status = NULL,
show_plot = TRUE
)Arguments
- top_targets
Top targets generated by prioritise_targets.
- save_dir
Where to store the file locally.
- drug_types
Filter results by drug type.
- highest_status
Filter results by drug approval status.
- show_plot
Show the plot.
Examples
top_targets <- MultiEWCE::example_targets$top_targets
top_targets <- HPOExplorer::add_genes(top_targets[q<0.05])
#> Reading cached RDS file: phenotype_to_genes.txt
#> + Version: v2023-10-09
res <- ttd_check(top_targets=top_targets)
#> Loading required namespace: readxl
#> Retrieving all organisms available in gprofiler.
#> Using stored `gprofiler_orgs`.
#> Mapping species name: hsapiens
#> 1 organism identified from search: hsapiens
#> 13,103 / 25,876 (50.64%) genes mapped.
